Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function
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چکیده
منابع مشابه
Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function.
Short bowel syndrome (SBS) is a devastating condition in which insufficient small intestinal surface area results in malnutrition and dependence on intravenous parenteral nutrition. There is an increasing incidence of SBS, particularly in premature babies and newborns with congenital intestinal anomalies. Tissue-engineered small intestine (TESI) offers a therapeutic alternative to the current s...
متن کاملCALL FOR PAPERS Intestinal Stem Cells in GI Physiology and Disease Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function
Christa N. Grant, Salvador Garcia Mojica, Frederic G. Sala, J. Ryan Hill, Daniel E. Levin, Allison L. Speer, Erik R. Barthel, Hiroyuki Shimada, Nicholas C. Zachos, and Tracy C. Grikscheit Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children’s Hospital Los Angeles, Los Angeles, California; Division of Pediatric Surgery, Children’s Hospital Los Angeles, USC ...
متن کاملHuman tissue-engineered small intestine forms from postnatal progenitor cells.
PURPOSE Tissue-engineered small intestine (TESI) represents a potential cure for short bowel syndrome (SBS). We previously reported full-thickness intestine formation using an organoid units-on-scaffold approach in rodent and swine models. Transplanted intestinal xenografts have been documented to survive from human fetal tissue but not from postnatal tissue. We now present the first report of ...
متن کاملAnastomosis between tissue-engineered intestine and native small bowel.
The purpose of this study was to demonstrate the feasibility of end-to-end anastomosis between tissue-engineered intestine and native small bowel and to investigate the effect of this anastomosis on their growth. Microporous biodegradable polymer tubes were created from a fiber mesh of polyglycolic acid sprayed with 5% polylactic acid. Intestinal epithelial organoid units were harvested from ne...
متن کاملEffect of diet on digestive and absorptive functions of rat small intestine.
Fractionation of epithelial cells of the small intestine has indicated that the brush border membrane binds many hydrolytic enzymes, such as maltase, sucrase, lactase, leucine aminopeptidase and alkaline phosphatase (1). Some of these enzymes have been believed to play a fundamental role in the terminal digestion of nutrients. The brush border was also identified as the site of absorption of di...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Gastrointestinal and Liver Physiology
سال: 2015
ISSN: 0193-1857,1522-1547
DOI: 10.1152/ajpgi.00111.2014